Animal / Human Pharmacological Activity

VIROFIT is a novel yet
innovative development

VIROFIT to prevent and control COVID-19, MERs, SARs and Influenza. VIROFIT can be used on all types of patients. VIROFIT medicine will be support not only COVID pandemic it will be support post-COVID time for initial stage of all antiviral, anti-inflammatory diseases and strengthen immune system.

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Proof of Concept

SR. No. Ingredients Clinical Indications
Nigella sativa Seed Extract

Inhibit pro inflammatory mediator like IL-1Beta,
IL-6 and TNF-Alpha¹,².

Polygonum cuspidatum
Root Extract

ACE II inhibitor³,⁴ and Inhibition of spike S1 Protein³

Curcuma longa Rhizome

TMPRSS2 inhibitor ⁵⁻⁷ and Sialic acid Inhibitor ⁸⁻¹¹

Sophora japonica
Flower Extract

Zn Ionophore ¹² and Inhibitor RNA dependent
RNA Polymerases Enzyme ¹³⁻¹⁶

Moringa oleifera Leave Extract

Anti-inflammatory effect by inhibition of
NF-κB pathway Activation ¹⁷⁻¹⁹

Glycyrrhiza glabra Root Extract

Gut health²⁰

Cichorium intybus Root Extract

Natural prebiotic²¹

Piper nigrum Fruit Extract

Bioavailability enhancer²²,²³ and Alkylating agent²⁴


[1] Shaterzadeh-Yazdi H, Noorbakhsh M-F, Hayati F, Samarghandian S, Farkhondeh T. Immunomodulatory and Antiinflammatory Effects of Thymoquinone. Cardiovasc Hematol Disord Drug Targets 2018;18:52–60.doi:10.2174/1871529X18666180212114816

[2] Umar S, Hedaya O, Singh AK, Ahmed S. Thymoquinone inhibits TNF-alpha-induced inflammation and cell adhesion in rheumatoid arthritis synovial fibroblasts by ASK1 regulation. Toxicol Appl Pharmacol 2015;287:299–305. doi:10.1016/j.taap.2015.06.017. 

[3] Ho T-Y, Wu S-L, Chen J-C, Li C-C, Hsiang C-Y. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction. Antiviral Res 2007;74:92–101. doi: 2006.04.014. 

[4] Olszanecki R, Bujak-Gizycka B, Madej J, Suski M, Wolkow PP, Jawien J, et al. Kaempferol, but not resveratrol inhibits angiotensin converting enzyme. J Physiol Pharmacol 2008;59:387–92. 

[5] Farooqi AA, Hou M-F, Chen C-C, Wang C-L, Chang H-W. Androgen receptor and gene network: Micromechanics reassemble the signaling machinery of TMPRSS2-ERG positive cancer cells. Cancer Cell Int 2014;14:34. doi:10.1186/1475-2867-14-34. 

[6] Li Y, Kong D, Wang Z, Ahmad A, Bao B, Padhye S, et al. Inactivation of AR/TMPRSS2-ERG/Wnt signaling networks attenuates the aggressive behavior of prostate cancer cells. Cancer Prev Res (Phila) 2011;4:1495–506. doi:10.1158/1940-6207.CAPR-11-0077. 

[7] Thangapazham R, Shaheduzzaman S, Kim K-H, Passi N, Tadese A, Vahey M, et al. Androgen responsive and refractory prostate cancer cells exhibit distinct curcumim regulated transcriptome. Cancer Biol Ther 2008;7:1427–35. doi:10.1016/S0022-5347(08)60553-4.

[8] Ou J-L, Mizushina Y, Wang S-Y, Chuang D-Y, Nadar M, Hsu W-L. Structure–activity relationship analysis of curcumin analogues on anti-influenza virus activity. FEBS J 2013;280:5829–40. doi:10.1111/febs.12503.

[9] Ozen N, Uslu E, Ozen M, Aydin S, Altug T, Belce A, et al. Curcumin’s Effects on Sialic Acid Level and Sialidase Activity in Ehrlich Ascites Tumor Bearing Mice Tohoku J Exp Med 2002;197:221–7. doi:10.1620/tjem.197.221.

[10] Richart SM, Li Y-L, Mizushina Y, Chang Y-Y, Chung T-Y, Chen G-H, et al. Synergic effect of curcumin and its structural analogue (Monoacetylcurcumin) on anti-influenza virus infection. J Food Drug Anal 2018;26:1015–23.

[11] Kim BR, Park J-Y, Jeong HJ, Kwon H-J, Park S-J, Lee I-C, et al. Design, synthesis, and evaluation of curcumin analogues as potential inhibitors of bacterial sialidase.J Enzyme Inhib Med Chem 2018;33:1256–65. doi:10.1080/14756366.2018.1488695.

[12] Dabbagh-Bazarbachi H, Clergeaud G, Quesada IM, Ortiz M, O’Sullivan CK, Fernandez-Larrea JB. Zinc ionophore activity of quercetin and epigallocatechin- gallate: from Hepa 1-6 cells to a liposome model. J Agric Food Chem 2014;62:8085–93.doi:10.1021/jf5014633.

[13] Ono K, Nakane H, Fukushima M, Chermann JC, Barré-Sinoussi F. Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases. Eur J Biochem 1990;190:469–76 oi:10.1111/j.1432-1033.1990.tb15597.x.

[14] Shinozuka K, Kikuchi Y, Nishino C, Mori A, Tawata S. Inhibitory effect of flavonoids on DNA-dependent DNA and RNA polymerases. Experientia 1988;44:882– 5. doi:10.1007/BF01941188.

[15] Yao C, Xi C, Hu K, Gao W, Cai X, Qin J, et al. Inhibition of enterovirus 71 replication and viral 3C protease by quercetin. Virol J 2018;15:116. doi: 10.1186s12985-018-1023-6.

[16] Ahmed-Belkacem A, Guichou J-F, Brillet R, Ahnou N, Hernandez E, Pallier C, et al. Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention. Nucleic Acids Res 2014;42:9399–409. doi:10.1093/nar/gku632.

[17] Su S, Li X, Li S, Ming P, Huang Y, Dong Y, et al. Rutin protects against lipopolysaccharide-induced mastitis by inhibiting the activation of the NF-kappaB signalling pathway and attenuating endoplasmic reticulum stress. Inflammopharmacology 2019;27:77–88. doi:10.1007s10787-018-0521-x.

[18] Al-Harbi NO, Imam F, Al-Harbi MM, Al-Shabanah OA, Alotaibi MR, As Sobeai HM, et al. Rutin inhibits carfilzomib-induced oxidative stress and inflammation via the NOS-mediated NF-κB signaling pathway. Inflammopharmacology 2019;27:817–27. doi:10.1007/s10787-018-0550-5.

[19] Fei J, Sun Y, Duan Y, Xia J, Yu S, Ouyang P, et al. Low concentration of rutin treatment might alleviate the cardiotoxicity effect of pirarubicin on cardiomyocytes via activation of PI3K/AKT/mTOR signaling pathway. Biosci Rep 2019;39. doi:10.1042/BSR20190546.

[20] Kadur Ramamurthy Raveendra, An Extract of Glycyrrhiza glabra (GutGard) AlleviatesSymptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study, Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 216970, 9 pages.

[21] Renée A. Street et. Al., Cichorium intybus: Traditional Uses, Phytochemistry, Pharmacology, and Toxicology, Hindawi Publishing Corporation, Evidence-Based Complementary and Alternative Medicine Volume 2013, Article ID 579319, 13 pages.

[22] Goswami TK, Meghwal M. Chemical Composition, Nutritional, Medicinal And Functional Properties of Black Pepper: A Review. J Nutr Food Sci 2012;01. doi: 10.4172/ scientificreports. 172.

[23] Gorgani L, Mohammadi M, Najafpour GD, Nikzad M. Piperine—The Bioactive Compound of Black Pepper: From Isolation to Medicinal Formulations. Compr Rev Food Sci Food Saf 2017;16:124–40. doi:10.1111/1541-4337.12246.

[24] Panda AK, Chakraborty D, Sarkar I, Khan T, Sa G. New insights into therapeutic activity and anticancer properties of curcumin. J Exp Pharmacol 2017;9:31–45. doi:10.2147/JEP.S705