Animal / Human Pharmacological Activity

VIROFIT Extra is a novel yet
innovative development

VIROFIT Extra to prevent and control COVID-19, MERs, SARs and Influenza. It can be used on all types of patients. This  medicine will be support not only COVID pandemic it will be support post-COVID time for symptomatic relief at initial stage of all antiviral, anti-inflammatory diseases and respiratory support.

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Proof of Concept

SR. No. Ingredients Clinical Indications
Nigella sativa Seed Extract

Inhibit pro inflammatory mediator like IL-1Beta,
IL-6 and TNF-Alpha¹,².

Polygonum cuspidatum
Root Extract

ACE II inhibitor³,⁴ and Inhibition of spike S1 Protein³

Curcuma longa Rhizome

TMPRSS2 inhibitor ⁵⁻⁷ and Sialic acid Inhibitor ⁸⁻¹¹

Sophora japonica
Flower Extract

Zn Ionophore ¹² and Inhibitor RNA dependent
RNA Polymerases Enzyme ¹³⁻¹⁶

Moringa oleifera Leave Extract

Anti-inflammatory effect by inhibition of
NF-κB pathway Activation ¹⁷⁻¹⁹

Salvia miltiorrhiza
Root Extract

Anti-coronavirus agents through Inhibition of Spike
protein S1 Amino side²⁰,²¹

Silybum marianum
Fruit Extract

Inhibits NS5B RNA dependent RNA Polymerase²²,²³
and Proteases Inhibitor²⁴

Adhatoda vasica
Leaves Extract

Bioavailability enhancer²²,²³ and Alkylating agent²⁴

Gymnema sylvestre
Leaves Extract


Glycyrrhiza glabra
Root Extract

Gut health³⁴

Cichorium intybus
Root Extract

Natural prebiotic³⁵

Piper nigrum Fruit Extract

Bioavailability enhancer³⁶,³⁷ and Alkylating agent³⁸


[1] Shaterzadeh-Yazdi H, Noorbakhsh M-F, Hayati F, Samarghandian S, Farkhondeh T. Immunomodulatory and Anti-inflammatory Effects of Thymoquinone. Cardiovasc Hematol Disord Drug Targets 2018;18:52–60 oi:10.2174/1871529X18666180212114816

[2] Umar S, Hedaya O, Singh AK, Ahmed S. Thymoquinone inhibits TNF-alpha-induced inflammation and cell adhesion in rheumatoid arthritis synovial fibroblasts by ASK1 regulation. Toxicol Appl Pharmacol 2015;287:299–305. doi:10.1016/j.taap.2015.06.017.

[3] Ho T-Y, Wu S-L, Chen J-C, Li C-C, Hsiang C-Y. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction. Antiviral Res 2007;74:92–101. doi:

[4] Olszanecki R, Bujak-Gizycka B, Madej J, Suski M, Wolkow PP, Jawien J, et al. Kaempferol, but not resveratrol inhibits angiotensin converting enzyme. J Physiol Pharmacol 2008;59:387–92.

[5] Farooqi AA, Hou M-F, Chen C-C, Wang C-L, Chang H-W. Androgen receptor and gene network: Micromechanics reassemble the signaling machinery of TMPRSS2-ERG positive cancer cells. Cancer Cell Int 2014;14:34.doi:10.1186/1475-2867-14-34.

[6] Li Y, Kong D, Wang Z, Ahmad A, Bao B, Padhye S, et al. Inactivation of AR/TMPRSS2-ERG/Wnt signaling networks attenuates the aggressive behavior of prostate cancer cells. Cancer Prev Res (Phila) 2011;4:1495–506. doi:10.1158/1940-6207.- CAPR-11-0077.

[7] Thangapazham R, Shaheduzzaman S, Kim K-H, Passi N, Tadese A, Vahey M, et al. Androgen responsive and refractory prostate cancer cells exhibit distinct curcumim regulated transcriptome. Cancer Biol Ther 2008;7:1427–35. doi:10.1016/S0022-5347(08)60553-4.

[8] Ou J-L, Mizushina Y, Wang S-Y, Chuang D-Y, Nadar M, Hsu W-L. Structure–activity relationship analysis of curcumin analogues on anti-influenza virus activity. FEBS J 2013;280:5829–40. doi:10.1111/febs.12503.

[9] Ozen N, Uslu E, Ozen M, Aydin S, Altug T, Belce A, et al. Curcumin’s Effects on Sialic Acid Level and Sialidase Activity in Ehrlich Ascites Tumor Bearing Mice Tohoku J Exp Med 2002;197:221–7. doi:10.1620/tjem.197.221.

[10] Richart SM, Li Y-L, Mizushina Y, Chang Y-Y, Chung T-Y, Chen G-H, et al. Synergic effect of curcumin and its structural analogue (Monoacetylcurcumin) on anti-influenza virus infection. J Food Drug Anal 2018;26:1015–23. doi:

[11] Kim BR, Park J-Y, Jeong HJ, Kwon H-J, Park S-J, Lee I-C, et al. Design, synthesis, and evaluation of curcumin analogues as potential inhibitors of bacterial sialidase.J Enzyme Inhib Med Chem 2018;33:1256–65. doi:10.1080/14756366.2018.1488695.

[12] Dabbagh-Bazarbachi H, Clergeaud G, Quesada IM, Ortiz M, O’Sullivan CK, Fernandez-Larrea JB. Zinc ionophore activity of quercetin and epigallocatechin-gallate: from Hepa 1-6 cells to a liposome model. J Agric Food Chem 2014;62:8085–93. doi:10.1021/jf5014633.

[13] Ono K, Nakane H, Fukushima M, Chermann JC, Barré-Sinoussi F. Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases. Eur J Biochem 1990;190:469–76. doi:10.1111/j.1432-1033.1990.tb15597.x.

[14] Shinozuka K, Kikuchi Y, Nishino C, Mori A, Tawata S. Inhibitory effect of flavonoids on DNA-dependent DNA and RNA polymerases. Experientia 1988;44:882– 5. doi:10.1007/BF01941188.

[15] Yao C, Xi C, Hu K, Gao W, Cai X, Qin J, et al. Inhibition of enterovirus 71 replication and viral 3C protease by quercetin. VirolJ 2018;15:116. doi: 10.1186s12985-018-1023-6.

[16] Ahmed-Belkacem A, Guichou J-F, Brillet R, Ahnou N, Hernandez E, Pallier C, et al. Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention. Nucleic Acids Res 2014;42:9399–409. doi:10.1093/nar/gku632.

[17] Su S, Li X, Li S, Ming P, Huang Y, Dong Y, et al. Rutin protects against lipopolysaccharide-induced mastitis by inhibiting the activation of the NF-kappaB signalling pathway and attenuating endoplasmic reticulum stress. Inflammopharmacology 2019;27:77–88. doi:10.1007s10787-018-0521-x.

[18] Al-Harbi NO, Imam F, Al-Harbi MM, Al-Shabanah OA, Alotaibi MR, As Sobeai HM, et al. Rutin inhibits carfilzomib-induced oxidative stress and inflammation via the NOS-mediated NF-κB signaling pathway. Inflammopharmacology 2019;27:817–27. doi:10.1007/s10787-018-0550-5.

[19] Fei J, Sun Y, Duan Y, Xia J, Yu S, Ouyang P, et al. Low concentration of rutin treatment might alleviate the cardiotoxicity effect of pirarubicin on cardiomyocytes via activation of PI3K/AKT/mTOR signaling pathway. Biosci Rep 2019;39. doi:10.1042/BSR20190546.

[20] Zhang D, Wu K, Zhang X, Deng S, Peng B. In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus. J Integr Med 2020;18:152–8. doi:

[21] Chen L, Gui C, Luo X, Yang Q, Günther S, Scandella E, et al. Cinanserin Is an Inhibitor of the 3C-Like Proteinase of Severe Acute Respiratory Syndrome Coronavirus and Strongly Reduces Virus Replication In Vitro. J Virol 2005;79:7095–103. doi:10.1128/JVI.79.11.7095-7103.2005.

[22] Ahmed-Belkacem A, Ahnou N, Barbotte L, Wychowski C, Pallier C, Brillet R, et al. Silibinin and related compounds are direct inhibitors of hepatitis C virus RNA-dependent RNA polymerase. Gastroenterology 2010;138:1112–22. doi:10.1053/j.gastro.2009.11.053

[23] Wagoner J, Morishima C, Graf T, Oberlies N, Teissier E, Pécheur E-I, et al. Differential In Vitro Effects of Intravenous versus Oral Formulations of Silibinin on the HCV Life Cycle and Inflammation. PLoS One 2011;6:e16464. doi:10.1371/journal.pone.0016464.

[24] Molto J, Valle M, Miranda C, Cedeno S, Negredo E, Clotet B. Effect of milk thistle on the pharmacokinetics of darunavir-ritonavir in HIV-infected patients. Antimicrob Agents Chemother 2012;56:2837–41. doi:10.1128/AAC.00025-12.

[25] Amin AH, Mehta DR. A Bronchodilator Alkaloid (Vasicinone) from Adhatoda vasica Nees. Nature 1959;184:1317.-doi:10.1038/1841317a0

[26] Liu W, Wang Y, He D, Li S, Zhu Y, Jiang B, et al. Antitussive, expectorant, and bronchodilating effects of quinazoline alkaloids (+/-)-vasicine, deoxyvasicine, and (+/-)-vasicinone from aerial parts of Peganum harmala L. Phytomedicine 2015;22:1088–95. doi:10.1016/j.phymed.2015.08.005

[27] Mehta DR, Naravane JS, Desai RM. Vasicinone. A Bronchodilator Principle from Adhatoda Vasica Nees (N.O. Acanthaceae). J Org Chem 1963;28:445–8. doi:10.1021/jo01037a041.

[28] R R, Basu S, Pant M, Priyanka K, Sonam S. Review & Future Perspectives of Using Vasicine, and Related Compounds. Indo-Global J Pharm Sci 2011;10.

[29] Gopalakrishnan R, Vikrant B, Sandur S, Sharma A, Pushpa K. Accumulation of vasicine and vasicinone in tissue cultures of Adhatoda vasica and evaluation of the free radical-scavenging activities of the various crude extracts. Food Chem 2010;126:1033–8.doi:10.1016/j.foodchem.2010.11.115.

[30] Mali RG, Dhake AS. A review on herbal antiasthmatics. Orient Pharm Exp Med 2011;11:77–90. doi:10.1007/s13596-011-0019-1.

[31] Singh VK, Dwivedi P, Chaudhary BR, Singh R. Immunomodulatory Effect of Gymnema sylvestre (R.Br.) Leaf Extract: An In Vitro Study in Rat Model. PLoS One 2015;10:e0139631. doi:10.1371/journal.pone.0139631.

[32] Tiwari P, Mishra BN, Sangwan NS. Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. Biomed Res Int 2014;2014:830285.doi:10.1155/2014/830285.

[33] Singh VK, Dwivedi P, Chaudhary BR, Singh R. Gymnemic Acid Stimulates In Vitro Splenic Lymphocyte Proliferation. Phytother Res 2016; 30:341–4. doi:10.1002/ptr.5514.

[34] Kadur Ramamurthy Raveendra, An Extract of Glycyrrhiza glabra (GutGard) AlleviatesSymptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study, Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 216970, 9 pages.

[35] Renée A. Street et. Al., Cichorium intybus: Traditional Uses, Phytochemistry, Pharmacology, and Toxicology, Hindawi Publishing Corporation, Evidence-Based Complementary and Alternative Medicine Volume 2013, Article ID 579319, 13 pages.

[36] Goswami TK, Meghwal M. Chemical Composition, Nutritional, Medicinal And Functional Properties of Black Pepper: A Review. J Nutr Food Sci 2012;01. doi: 10.4172/ scientificreports. 172.

[37] Gorgani L, Mohammadi M, Najafpour GD, Nikzad M. Piperine—The Bioactive Compound of Black Pepper: From Isolation to Medicinal Formulations. Compr Rev Food Sci Food Saf 2017;16:124–40. doi:10.1111/1541-4337.12246.

[38] Panda AK, Chakraborty D, Sarkar I, Khan T, Sa G. New insights into therapeutic activity and anticancer properties of curcumin. J Exp Pharmacol 2017;9:31–45. doi:10.2147/JEP.S70